Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia

Overview of attention for article published in Arthritis & Rheumatology, March 2023

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In the top 5% of all research outputs scored by Altmetric
High Attention Score compared to outputs of the same age (98th percentile)
High Attention Score compared to outputs of the same age and source (93rd percentile)

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丁度A&Rで関連するのを読んだので。 lubricinが尿酸結晶沈着と、IL-1βによるマクロファージからのキサンチンオキシダーゼ・尿酸の誘導を抑えてる。高尿酸血症のない痛風患者では遺伝子変異によるlubricinの抑制が起きている可能性。 https://t.co/zC169YEqZR

RT @Tuhina_Neogi: Really interesting case of a female without hyperuricemia having crystal-proven gouty erosions related to lubricin defici…

Potential #ACRKnowledgeBowl question, and an interesting detective story 🕵️🔎

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