Age-related macular degeneration (AMD) is the leading cause of blindness in ageing societies and is caused by both environmental and genetic factors. The strongest genetic signal for AMD with odds ratios of up to 2.8 per adverse allele was found previously to center over two genes, ARMS2 and HTRA1 on 10q26, although with little knowledge as to the true functionally relevant gene or genetic variation. Due to extensive linkage disequilibrium (LD) at this locus, it was long assumed that the broad association signal cannot be dissected by statistical means. In this report, we have now separated the 10q26 region by analyzing imputed haplotypes with the help of a large case/control association data set. Rare recombinant haplotypes identified in 16,144 cases and 17,832 controls from the International AMD Genomics Consortium (IAMDGC), revealed genetic variants in ARMS2 but not HTRA1 to exclusively carry the AMD disease load with p values between 1.0x10(-773) and 6.7x10(-5) This study is a proof-of-concept and universally applicable to refine extended association signals providing the means to prioritize genes of interest for subsequent biological studies.
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
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#5,870,259
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#88,471
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Outputs of similar age from Genetics
#26
of 86 outputs
Altmetric has tracked 31,634,113 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,513 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
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We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
