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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Endoplasmic Reticulum Stress in the Brain Tumor Immune Microenvironment.
|
|---|---|
| Published in |
Molecular Cancer Research, January 2023
|
| DOI | 10.1158/1541-7786.mcr-22-0920 |
| Pubmed ID | |
| Authors |
Edgar Petrosyan, Jawad Fares, Luis G Fernandez, Ragini Yeeravalli, Crismita Dmello, Joseph T Duffy, Peng Zhang, Catalina Lee-Chang, Jason Miska, Atique U Ahmed, Adam M Sonabend, Irina V Balyasnikova, Amy B Heimberger, Maciej S Lesniak |
| Abstract |
Immunotherapy has emerged as a powerful strategy for halting cancer progression. However, primary malignancies affecting the brain have been exempt to this success. Indeed, brain tumors continue to portend severe morbidity and remain a globally lethal disease. Extensive efforts have been directed at understanding how tumor cells survive and propagate within the unique microenvironment of the central nervous system (CNS). Cancer genetic aberrations and metabolic abnormalities provoke a state of persistent endoplasmic reticulum (ER) stress that in turn promotes tumor growth, invasion, therapeutic resistance, and the dynamic reprogramming of the infiltrating immune cells. Consequently, targeting ER stress is a potential therapeutic approach. In this work, we provide an overview of how ER stress response is advantageous to brain tumor development, discuss the significance of ER stress in governing anti-tumor immunity, and put forth therapeutic strategies of regulating ER stress in order to augment the effect of immunotherapy for primary CNS tumors. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 50% |
| Portugal | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Scientists | 4 | 40% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 1 | 33% |
| Lecturer > Senior Lecturer | 1 | 33% |
| Unknown | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 33% |
| Computer Science | 1 | 33% |
| Unknown | 1 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 May 2023.
All research outputs
#4,359,141
of 23,923,788 outputs
Outputs from Molecular Cancer Research
#284
of 1,932 outputs
Outputs of similar age
#85,124
of 443,108 outputs
Outputs of similar age from Molecular Cancer Research
#4
of 21 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,932 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,108 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.