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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Strontium‐modified titanium substrate promotes osteogenic differentiation of MSCs and implant osseointegration via upregulating CDH2
|
|---|---|
| Published in |
Clinical Oral Implants Research, February 2023
|
| DOI | 10.1111/clr.14035 |
| Pubmed ID | |
| Authors |
Chuan Zhou, Ziyu Ge, Lu Song, Jiahui Yan, Xinrui Lang, Yanzhen Zhang, Fuming He |
| Abstract |
Cadherin-mediated cell-cell adhesion and signaling are critical for morphogenesis during skeletal development, but its role in the osteogenesis triggered by biomaterials is poorly understand. While our previous studies showed that strontium (Sr)-modified sand-blasted, large grit, acid etched titanium surface (Sr-SLA) is beneficial for osseointegration, the supporting mechanisms have not been explored in detail. In this study, transcriptome analysis of peri-implant bone tissue was performed, and N-cadherin (CDH2) was selected as a key mediator of Sr-SLA-mediated osseointegration. In vitro validation experiments have confirmed that indeed, CDH2 expression in MSCs on Sr-SLA was higher than the control group, which was in parallel with the enhanced cell migration, adhesion, and upregulation of early osteogenic markers. Knocking down CDH2 in MSCs resulted in decreased cell viability and osteogenic differentiation, and the elevated biocompatibility and osteoinductive effect of Sr-SLA were greatly diminished. Surprisingly, Sr-SLA-induced upregulation of CDH2 was not followed by restriction of β-catenin signaling because Sr-SLA also promoted the expression and nuclear translocation of β-catenin. In vivo, a recombinant adeno-associated virus 9 vector carrying an artificial siRNA that target CDH2 (AAV9-CDH2i) was intravenously injected in mice, followed by tibial surgery with implant placement. Accordingly, systemic administration of AAV9-CDH2i effectively knocked down CDH2 expression in bone marrow cells, and in turn, inhibited bone formation induced by Sr-SLA. The results indicated that CDH2 is required for Sr-SLA-mediated bone regeneration, which reveals a new mechanism to explain the osteoinductive effect of Sr-SLA. Thus, biomaterial modifications targeting CDH2 may help improve early osseointegration and bone healing. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 25% |
| Researcher | 1 | 25% |
| Other | 1 | 25% |
| Unknown | 1 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 50% |
| Unspecified | 1 | 25% |
| Unknown | 1 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#14,363,817
of 24,137,933 outputs
Outputs from Clinical Oral Implants Research
#552
of 1,209 outputs
Outputs of similar age
#191,175
of 449,141 outputs
Outputs of similar age from Clinical Oral Implants Research
#4
of 7 outputs
Altmetric has tracked 24,137,933 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,209 research outputs from this source. They receive a mean Attention Score of 2.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 449,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.