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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multi-antigen spherical nucleic acid cancer vaccines
|
|---|---|
| Published in |
Nature Biomedical Engineering, January 2023
|
| DOI | 10.1038/s41551-022-01000-2 |
| Pubmed ID | |
| Authors |
Michelle H. Teplensky, Michael Evangelopoulos, Jasper W. Dittmar, Connor M. Forsyth, Andrew J. Sinegra, Shuya Wang, Chad A. Mirkin |
| Abstract |
Cancer vaccines must activate multiple immune cell types to be effective against aggressive tumours. Here we report the impact of the structural presentation of two antigenic peptides on immune responses at the transcriptomic, cellular and organismal levels. We used spherical nucleic acid (SNA) nanoparticles to investigate how the spatial distribution and placement of two antigen classes affect antigen processing, cytokine production and the induction of memory. Compared with single-antigen SNAs, a single dual-antigen SNA elicited a 30% increase in antigen-specific T cell activation and a two-fold increase in T cell proliferation. Antigen placement within dual-antigen SNAs altered the gene expression of T cells and tumour growth. Specifically, dual-antigen SNAs encapsulating antigens targeting helper T cells and with externally conjugated antigens targeting cytotoxic T cells elevated antitumour genetic pathways, stalling lymphoma tumours in mice. Additionally, when combined with the checkpoint inhibitor anti-programmed-cell-death protein-1 in a mouse model of melanoma, a specific antigen arrangement within dual-antigen SNAs suppressed tumour growth and increased the levels of circulating memory T cells. The structural design of multi-antigen vaccines substantially impacts their efficacy. |
X Demographics
The data shown below were collected from the profiles of 124 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 30 | 24% |
| Canada | 7 | 6% |
| France | 4 | 3% |
| Brazil | 3 | 2% |
| United Kingdom | 3 | 2% |
| Mexico | 2 | 2% |
| Spain | 1 | <1% |
| India | 1 | <1% |
| Pakistan | 1 | <1% |
| Other | 10 | 8% |
| Unknown | 62 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 78 | 63% |
| Scientists | 31 | 25% |
| Practitioners (doctors, other healthcare professionals) | 10 | 8% |
| Science communicators (journalists, bloggers, editors) | 5 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Researcher | 10 | 14% |
| Student > Bachelor | 4 | 6% |
| Other | 4 | 6% |
| Student > Master | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 25 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 20% |
| Chemistry | 8 | 11% |
| Immunology and Microbiology | 6 | 9% |
| Engineering | 5 | 7% |
| Unspecified | 3 | 4% |
| Other | 7 | 10% |
| Unknown | 27 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 296. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#120,056
of 25,758,695 outputs
Outputs from Nature Biomedical Engineering
#57
of 1,153 outputs
Outputs of similar age
#3,083
of 476,978 outputs
Outputs of similar age from Nature Biomedical Engineering
#1
of 34 outputs
Altmetric has tracked 25,758,695 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 85.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 476,978 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.