Families with PCSK9 loss of function (LOF) mutations have exceedingly low risk of heart disease, with a very slight (if at all) increase in insulin resistance and obesity https://t.co/P5MZgRwP5c https://t.co/A2ofSsD7aW https://t.co/I1kF6WCbaj
Next-gen therapies are coming: • Antisense oligonucleotides (ASOs) • Liver-targeted siRNAs • Gene editing This is the goal—because it’s biologically plausible that we could effectively eliminate cardiovascular and cerebrovascular disease with lifelong A…
@BigDDaddyCali @MasalaFry69 @squirrelpalooza @Rizabellepow @ErinGoBragh360 Incorrect. Here is a Mendelain randomization study regarding genetic LDL irrelevant to diet- though accounted for in p value calculations: https://t.co/jIXEiQNWgV And of cours…
@cremieuxrecueil "The lower your LDL for longer, the better your health." Except for more diabetes. https://t.co/AYRggIUxNJ