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The immune paradox of SARS‐CoV‐2: Lymphocytopenia and autoimmunity evoking features in COVID‐19 and possible treatment modalities

Overview of attention for article published in Reviews in Medical Virology, February 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 784)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

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146 X users

Citations

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3 Dimensions

Readers on

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14 Mendeley
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Title
The immune paradox of SARS‐CoV‐2: Lymphocytopenia and autoimmunity evoking features in COVID‐19 and possible treatment modalities
Published in
Reviews in Medical Virology, February 2023
DOI 10.1002/rmv.2423
Pubmed ID
Authors

Joachim Gerlach, Abdul Mannan Baig, Mark Fabrowski, Valentina Viduto

Abstract

SARS-CoV-2 causes multiorgan damage to vital organs and tissue that are known to be due to a combination of tissue tropisms and cytokine-mediated damage that it can incite in COVID-19. The effects of SARS-Co-2 on the lymphocytes and therefore on the immune response have attracted attention recently in COVID-19 to understand its effects in causing a chronic state of ongoing infection with Long-COVID. The associated lymphopaenia and autoimmune disease state, which is an apparent paradox, needs to be researched to dissect possible mechanisms underlying this state. This paper attempts to unravel the aforesaid immune paradox effects of SARS-CoV-2 on the lymphocytes and discusses appropriate treatment modalities with antiviral drugs and nutraceuticals which could prove virucidal in SARS-CoV-2 seeding monocytes and lymphocytes in patients with COVID-19 and Long-COVID. Importantly it proposes a new in vitro treatment modality of immune regulating cells that can help patients fight the lymphopaenia associated with COVID-19 and Long-COVID.

X Demographics

X Demographics

The data shown below were collected from the profiles of 146 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 14%
Student > Doctoral Student 2 14%
Other 1 7%
Student > Bachelor 1 7%
Researcher 1 7%
Other 0 0%
Unknown 7 50%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 14%
Computer Science 1 7%
Psychology 1 7%
Medicine and Dentistry 1 7%
Engineering 1 7%
Other 0 0%
Unknown 8 57%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 80. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2024.
All research outputs
#550,976
of 26,004,690 outputs
Outputs from Reviews in Medical Virology
#31
of 784 outputs
Outputs of similar age
#12,618
of 479,760 outputs
Outputs of similar age from Reviews in Medical Virology
#2
of 22 outputs
Altmetric has tracked 26,004,690 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 784 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 479,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.