Alginate microparticles and nanoparticles crosslinked with Ca(+2) ions are frequently employed in biomedical applications. Here we use microemulsion polymerization to prepare alginate nanoparticles (nanogels) using different crosslinking ions (Ca(+2), Sr(+2), Ba(+2)) to encapsulate a model protein, urease enzyme (jackbeans). With alginate concentrations of 0.2wt% in the aqueous phase, emulsion droplets showed good stability and narrow, monomodal distributions with radii ∼65±10nm. The size of the nanogel varies with the crosslinking cation and its affinity for the mannuronate and guluronate units in the linear alginate chain. The nanogels were further characterized using dynamic light scattering, scanning electron microscopy, energy dispersive X-ray spectrometry and zeta potential. This work demonstrates the potential application of Ba-alginate as an alternative matrix for nano-encapsulation of proteins and its use for biomedical applications.
Pharmacology, Toxicology and Pharmaceutical Science
3
4%
Other
7
9%
Unknown
36
49%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2025.
All research outputs
#7,307,306
of 34,400,738 outputs
Outputs from Journal of Colloid & Interface Science
#1,081
of 10,162 outputs
Outputs of similar age
#84,487
of 340,013 outputs
Outputs of similar age from Journal of Colloid & Interface Science
#9
of 121 outputs
Altmetric has tracked 34,400,738 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,162 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,013 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.
