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EGF receptor modulates HEV entry in human hepatocytes

Overview of attention for article published in Hepatology, February 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
10 news outlets
blogs
1 blog
twitter
21 X users

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
7 Mendeley
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Title
EGF receptor modulates HEV entry in human hepatocytes
Published in
Hepatology, February 2023
DOI 10.1097/hep.0000000000000308
Pubmed ID
Authors

Jil A. Schrader, Thomas L. Burkard, Yannick Brüggemann, André Gömer, Toni L. Meister, Rebecca M. Fu, Ann-Kathrin Mehnert, Viet L. Dao Thi, Patrick Behrendt, David Durantel, Ruth Broering, Florian W. R. Vondran, Daniel Todt, Volker Kinast, Eike Steinmann

Abstract

Being the most common cause for acute viral hepatitis with more than 20 million cases per year and 70 000 deaths annually, hepatitis E virus (HEV) presents a long neglected and under-investigated health burden. Although the entry process of viral particles is an attractive target for pharmacological intervention, druggable host factors to restrict HEV entry have not been identified so far. Here we identify the epidermal growth factor receptor (EGFR) as a novel host factor for HEV and reveal the significance of EGFR for the HEV entry process. By utilizing RNAi, chemical modulation with FDA-approved drugs and ectopic expression of EGFR, we revealed that EGFR is critical for HEV infection, without affecting HEV RNA replication or assembly of progeny virus. We further unveiled that EGFR itself and its ligand binding domain rather than its signaling function is responsible for the proviral effect. Modulation of EGF expression in HepaRG cells as well as primary human hepatocytes affected HEV infection. Taken together, our study provides novel insights into the life cycle of HEV and identified EGFR as a possible target for future anti-viral strategies against HEV.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 29%
Researcher 1 14%
Student > Master 1 14%
Unknown 3 43%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 14%
Biochemistry, Genetics and Molecular Biology 1 14%
Agricultural and Biological Sciences 1 14%
Medicine and Dentistry 1 14%
Unknown 3 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 87. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2023.
All research outputs
#487,786
of 25,394,764 outputs
Outputs from Hepatology
#127
of 9,095 outputs
Outputs of similar age
#11,238
of 473,425 outputs
Outputs of similar age from Hepatology
#5
of 126 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,095 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 473,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.