Title |
BNT162b2 mRNA COVID-19ワクチン接種後に発症した後天性血友病A
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Published in |
[Rinshō ketsueki] The Japanese journal of clinical hematology, February 2023
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DOI | 10.11406/rinketsu.64.35 |
Pubmed ID | |
Authors |
Ayami Senda, Hideaki Saito, Shinsuke Kusakabe, Koki Yoshida, Kumi Shibata, Shuhei Kida, Jun Toda, Akihisa Hino, Tomoaki Ueda, Jiro Fujita, Kentaro Fukushima, Takafumi Yokota, Hirokazu Kashiwagi, Naoki Hosen |
Abstract |
Acquired hemophilia A (AHA) is a rare disease characteized by bleeding symptoms caused by decreased factor VIII activity due to the appearance of inhibitors to factor VIII triggered by malignancy or collagen disease. An 86-year-old woman developed purpura on her extremities after the first dose of the BNT162b2 mRNA COVID-19 vaccine. This symptom subsided after a few days. After the second dose of the BNT162b2 mRNA COVID-19 vaccine, purpura appeared again, and the patient was referred to our hospital Her APTT was remarkably prolonged to 110 seconds, and a cross-mixing test revealed an inhibitor pattern. Since FVIII activity was <1% and FVIII inhibitor was 51.6 BU, she was diagnosed with AHA. Prednisolone therapy was started, and coagulative complete remission was achieved. Because acquired hemophilia can develop after mRNA COVID-19 vaccination, as in this case, it is critical to monitor the appearance of bleeding symptom. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 3 | 7% |
United States | 3 | 7% |
Spain | 2 | 5% |
Sweden | 1 | 2% |
Lesotho | 1 | 2% |
Unknown | 31 | 76% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 40 | 98% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |