Organoarsenicals, such as Lewisite and related chloroarsine, Di-phenyl Chloro Arsine (DPCA), are chemical warfare agents developed during WWI. Stockpiles in Eastern Europe remain a threat to humans. The well-documented effects of cutaneous exposure to these organoarsenicals include skin blisters, painful burns, and life-threatening conditions such as Acute Respiratory Distress Syndrome. In survivors, long-term effects such as the development of respiratory ailments are reported for the organoarsenical sulfur mustard (SM), however no long-term pulmonary effects are documented for lewisite and DPCA. No animal models exist to explore the relationship between skin exposure to arsenicals and constrictive bronchiolitis. We developed and characterized a mouse model to study the long-term effects of cutaneous exposure on the lungs in survivors. We exposed mice to lewisite, DPCA, or a less toxic surrogate organo-arsenic chemical phenyl arsine oxide (PAO) on the skin. The surviving mice were followed for 20 weeks following skin exposure to arsenicals. The lung micro-computed tomography, lung function, and histology demonstrated increased airway resistance, increased thickness of the smooth muscle layer, increased collagen deposition in the sub-epithelium, and l peribronchial lymphocyte infiltration in the mice exposed to arsenical on skin.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2023.
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#12,463,481
of 34,640,154 outputs
Outputs from American Journal of Respiratory Cell and Molecular Biology
#1,888
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Outputs of similar age
#162,676
of 439,144 outputs
Outputs of similar age from American Journal of Respiratory Cell and Molecular Biology
#19
of 51 outputs
Altmetric has tracked 34,640,154 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,398 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,144 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
