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X Demographics
Mendeley readers
Attention Score in Context
| Title |
On-demand male contraception via acute inhibition of soluble adenylyl cyclase
|
|---|---|
| Published in |
Nature Communications, February 2023
|
| DOI | 10.1038/s41467-023-36119-6 |
| Pubmed ID | |
| Authors |
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin |
| Abstract |
Nearly half of all pregnancies are unintended; thus, existing family planning options are inadequate. For men, the only choices are condoms and vasectomy, and most current efforts to develop new contraceptives for men impact sperm development, meaning that contraception requires months of continuous pretreatment. Here, we provide proof-of-concept for an innovative strategy for on-demand contraception, where a man would take a birth control pill shortly before sex, only as needed. Soluble adenylyl cyclase (sAC) is essential for sperm motility and maturation. We show a single dose of a safe, acutely-acting sAC inhibitor with long residence time renders male mice temporarily infertile. Mice exhibit normal mating behavior, and full fertility returns the next day. These studies define sAC inhibitors as leads for on-demand contraceptives for men, and they provide in vivo proof-of-concept for previously untested paradigms in contraception; on-demand contraception after just a single dose and pharmacological contraception for men. |
X Demographics
The data shown below were collected from the profiles of 318 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 88 | 28% |
| France | 9 | 3% |
| Japan | 8 | 3% |
| Canada | 7 | 2% |
| United Kingdom | 6 | 2% |
| Saudi Arabia | 4 | 1% |
| Spain | 4 | 1% |
| Costa Rica | 3 | <1% |
| Nigeria | 3 | <1% |
| Other | 34 | 11% |
| Unknown | 152 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 274 | 86% |
| Scientists | 28 | 9% |
| Practitioners (doctors, other healthcare professionals) | 9 | 3% |
| Science communicators (journalists, bloggers, editors) | 7 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 9% |
| Researcher | 7 | 7% |
| Professor | 7 | 7% |
| Student > Ph. D. Student | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 48 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Agricultural and Biological Sciences | 7 | 7% |
| Chemistry | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Nursing and Health Professions | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 53 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3662. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2024.
All research outputs
#1,493
of 25,774,185 outputs
Outputs from Nature Communications
#20
of 58,400 outputs
Outputs of similar age
#43
of 494,454 outputs
Outputs of similar age from Nature Communications
#1
of 1,732 outputs
Altmetric has tracked 25,774,185 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 58,400 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 494,454 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,732 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.