Title |
Postoperative delirium, neuroinflammation, and influencing factors of postoperative delirium: A review
|
---|---|
Published in |
Medicine (Wolters Kluwer), February 2023
|
DOI | 10.1097/md.0000000000032991 |
Pubmed ID | |
Authors |
M. Z. Xiao, C. X. Liu, L. G. Zhou, Y. Yang, Y. Wang |
Abstract |
Postoperative delirium (POD) is an acute cognitive dysfunction that is mainly characterized by memory impairment and disturbances in consciousness. POD can prolong the hospital stay and increase the 1-month mortality rate of patients. The overall incidence of POD is approximately 23%, and its prevalence can go up to 50% in high-risk surgeries. Neuroinflammation is an important pathogenic mechanism of POD that mediates microglial activation and leads to synaptic remodeling. Neuroinflammation, as an indispensable pathogenesis of POD, can occur due to a variety of factors, including aseptic inflammation caused by surgery, effects of anesthetic drugs, disruption of the blood-brain barrier, and epigenetics. Understanding these factors and avoiding the occurrence of risk factors may help prevent POD in time. This review provides a brief overview of POD and neuroinflammation and summarizes various factors affecting POD development mediated by neuroinflammation, which may serve as future targets for the prevention and treatment of POD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 23 | 24% |
United Kingdom | 5 | 5% |
Ecuador | 3 | 3% |
Spain | 2 | 2% |
United States | 2 | 2% |
India | 2 | 2% |
Venezuela, Bolivarian Republic of | 2 | 2% |
Comoros | 1 | 1% |
Guatemala | 1 | 1% |
Other | 6 | 6% |
Unknown | 48 | 51% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 90 | 95% |
Practitioners (doctors, other healthcare professionals) | 5 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 22% |
Lecturer | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Researcher | 1 | 6% |
Other | 2 | 11% |
Unknown | 8 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 44% |
Nursing and Health Professions | 1 | 6% |
Materials Science | 1 | 6% |
Social Sciences | 1 | 6% |
Unknown | 7 | 39% |