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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural and dynamic effects of pseudouridine modifications on noncanonical interactions in RNA.
|
|---|---|
| Published in |
RNA, March 2023
|
| DOI | 10.1261/rna.079506.122 |
| Pubmed ID | |
| Authors |
Jennifer Vögele, Elke Duchardt-Ferner, Holger Kruse, Zhengyue Zhang, Jiri Sponer, Miroslav Krepl, Jens Wöhnert |
| Abstract |
Pseudouridine is the most frequently naturally occurring RNA modification, found in all classes of biologically functional RNAs. Compared to uridine, pseudouridine contains an additional hydrogen bond donor group and is therefore widely regarded as a structure stabilizing modification. However, the effects of pseudouridine modifications on the structure and dynamics of RNAs have so far been only investigated in a limited number of different structural contexts. Here, we introduced pseudouridine modifications into the U-turn motif and the adjacent U:U closing base pair of the neomycin-sensing riboswitch (NSR) - an extensively characterized model system for RNA structure, ligand binding and dynamics. We show that the effects of replacing specific uridines with pseudouridines on RNA dynamics crucially depend on the exact location of the replacement site and can range from destabilizing to locally or even globally stabilizing. By using a combination of NMR spectroscopy, MD simulations and QM calculations, we rationalize the observed effects on a structural and dynamical level. Our results will help to better understand and predict the consequences of pseudouridine modifications on the structure and function of biologically important RNAs. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 6 | 14% |
| United States | 4 | 9% |
| France | 3 | 7% |
| India | 2 | 5% |
| Canada | 2 | 5% |
| Australia | 2 | 5% |
| Spain | 2 | 5% |
| United Kingdom | 1 | 2% |
| Chile | 1 | 2% |
| Other | 5 | 12% |
| Unknown | 15 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 63% |
| Scientists | 16 | 37% |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 33% |
| Professor | 2 | 17% |
| Student > Ph. D. Student | 2 | 17% |
| Student > Bachelor | 1 | 8% |
| Other | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 5 | 42% |
| Biochemistry, Genetics and Molecular Biology | 4 | 33% |
| Unknown | 3 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2023.
All research outputs
#1,394,948
of 24,811,594 outputs
Outputs from RNA
#62
of 3,142 outputs
Outputs of similar age
#28,490
of 410,982 outputs
Outputs of similar age from RNA
#3
of 51 outputs
Altmetric has tracked 24,811,594 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,142 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 410,982 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.