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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome
|
|---|---|
| Published in |
Epigenetics, March 2023
|
| DOI | 10.1080/15592294.2023.2185742 |
| Pubmed ID | |
| Authors |
Aleix Noguera-Castells, Carlos A. García-Prieto, Damiana Álvarez-Errico, Manel Esteller |
| Abstract |
DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans. On top of that, the DNA methylome undergoes profound changes in cancer and other disorders. However, large-scale and population-based studies are limited by high costs and the need for considerable expertise in data analysis for whole-genome bisulphite-sequencing methodologies. Following the success of the EPIC DNA methylation microarray, the newly developed Infinium HumanMethylationEPIC version 2.0 (900K EPIC v2) is now available. This new array contains more than 900,000 CpG probes covering the human genome and excluding masked probes from the previous version. The 900K EPIC v2 microarray adds more than 200,000 probes covering extra DNA cis-regulatory regions such as enhancers, super-enhancers and CTCF binding regions. Herein, we have technically and biologically validated the new methylation array to show its high reproducibility and consistency among technical replicates and with DNA extracted from FFPE tissue. In addition, we have hybridized primary normal and tumoural tissues and cancer cell lines from different sources and tested the robustness of the 900K EPIC v2 microarray when analysing the different DNA methylation profiles. The validation highlights the improvements offered by the new array and demonstrates the versatility of this updated tool for characterizing the DNA methylome in human health and disease. |
X Demographics
The data shown below were collected from the profiles of 43 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 26% |
| Spain | 8 | 19% |
| Singapore | 2 | 5% |
| Japan | 2 | 5% |
| Indonesia | 1 | 2% |
| Norway | 1 | 2% |
| Canada | 1 | 2% |
| Cameroon | 1 | 2% |
| Unknown | 16 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 60% |
| Scientists | 14 | 33% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 22% |
| Student > Ph. D. Student | 9 | 18% |
| Student > Master | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 15 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 45% |
| Medicine and Dentistry | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Environmental Science | 1 | 2% |
| Physics and Astronomy | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 17 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2023.
All research outputs
#1,088,370
of 25,367,237 outputs
Outputs from Epigenetics
#32
of 1,275 outputs
Outputs of similar age
#23,321
of 423,862 outputs
Outputs of similar age from Epigenetics
#2
of 22 outputs
Altmetric has tracked 25,367,237 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,275 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,862 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.