Barrett, Lindsey M, Meighan, Peter C, Mitchell, Diana M, Varnum, Michael D, Stenkamp, Deborah L, Barrett, Lindsey M., Meighan, Peter C., Mitchell, Diana M., Varnum, Michael D., Stenkamp, Deborah L.
Abstract
Adult zebrafish respond to retinal injury with a regenerative response that replaces damaged neurons with Müller glia-derived regenerated neurons. The regenerated neurons are functional, appear to make appropriate synaptic connections, and support visually mediated reflexes and more complex behaviors. Curiously, the electrophysiology of damaged, regenerating, and regenerated zebrafish retina has only recently been examined. In our previous work, we demonstrated that electroretinogram (ERG) recordings of damaged zebrafish retina correlate with the extent of the inflicted damage and that the regenerated retina at 80 days post-injury exhibited ERG waveforms consistent with functional visual processing. In this paper we describe the procedure for obtaining and analyzing ERG recordings from adult zebrafish previously subjected to widespread lesions that destroy inner retinal neurons and engage a regenerative response that restores retinal function, in particular the synaptic connections between photoreceptor axon terminals and the dendritic trees of retinal bipolar neurons.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2023.
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#14,641,668
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Outputs of similar age from Methods in molecular biology
#96
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Altmetric has tracked 25,436,226 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,189 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
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We're also able to compare this research output to 713 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.
