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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
|
|---|---|
| Published in |
Biochemistry, March 2023
|
| DOI | 10.1021/acs.biochem.3c00029 |
| Pubmed ID | |
| Authors |
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth |
| Abstract |
The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces opioid-independent analgesia, and regulates food intake. Recent studies indicate that biasing NTSR1 toward β-arrestin signaling can attenuate the actions of psychostimulants and other drugs of abuse. Here, we provide the cryoEM structures of NTSR1 ternary complexes with heterotrimeric Gq and GoA with and without the brain-penetrant small-molecule SBI-553. In functional studies, we discovered that SBI-553 displays complex allosteric actions exemplified by negative allosteric modulation for G proteins that are Gα subunit selective and positive allosteric modulation and agonism for β-arrestin translocation at NTSR1. Detailed structural analysis of the allosteric binding site illuminated the structural determinants for biased allosteric modulation of SBI-553 on NTSR1. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 41% |
| Japan | 7 | 10% |
| Canada | 2 | 3% |
| Thailand | 1 | 1% |
| India | 1 | 1% |
| Belgium | 1 | 1% |
| Togo | 1 | 1% |
| United Kingdom | 1 | 1% |
| Kenya | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 24 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 34 | 49% |
| Scientists | 32 | 46% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 23% |
| Student > Ph. D. Student | 4 | 15% |
| Student > Doctoral Student | 1 | 4% |
| Student > Bachelor | 1 | 4% |
| Other | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 10 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 15% |
| Neuroscience | 2 | 8% |
| Computer Science | 1 | 4% |
| Chemistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 13 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2024.
All research outputs
#1,221,641
of 25,765,370 outputs
Outputs from Biochemistry
#77
of 22,392 outputs
Outputs of similar age
#26,010
of 429,138 outputs
Outputs of similar age from Biochemistry
#1
of 76 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,392 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,138 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.