Title |
Alterations in Epidermal Biophysical Properties in Autistic Children
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Published in |
Skin Pharmacology and Physiology, March 2023
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DOI | 10.1159/000530140 |
Pubmed ID | |
Authors |
Bin Wang, You-Dong Li, Zi-Yan Wang, Jia-Qing Zhao, Guo-Qiang Zhang, Mao-Qiang Man |
Abstract |
Autism is a neurodevelopmental disorder. Individuals with autism can exhibit multiple neurological symptoms such as deficit in social communication, restricted interests and repetitive behaviors. Recent study showed that murine model of autism displays an increased transepidermal water loss (TEWL) and dry skin. But whether epidermal functions are also altered in children with autism is unknown. In the present study, TEWL, stratum corneum hydration and skin surface pH were compared between children with autism (N=56) and normal controls (N=48). Our results showed that children with autism exhibited lower stratum corneum hydration levels, higher TEWL and elevated skin surface pH in comparison to normal controls (p<0.0001 for all). These results demonstrate that children with autism exhibit epidermal dysfunction. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Finland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |