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Synthesis of a DOTA−Biotin Conjugate for Radionuclide Chelation via Cu-Free Click Chemistry

Overview of attention for article published in Organic Letters, April 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

blogs
1 blog
patent
13 patents
wikipedia
1 Wikipedia page

Readers on

mendeley
91 Mendeley
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Article details
Title
Synthesis of a DOTA−Biotin Conjugate for Radionuclide Chelation via Cu-Free Click Chemistry
Published in
Organic Letters, April 2010
DOI 10.1021/ol100774p
Pubmed ID
Authors
Abstract

A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.

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Mendeley demographics

Mendeley demographics

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Geographical breakdown

Geographical breakdown
Country Count As %
United States 4 4%
Netherlands 3 3%
Iran, Islamic Republic of 1 1%
Belgium 1 1%
Unknown 82 90%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Student > Ph. D. Student 29 32%
Researcher 19 21%
Student > Master 11 12%
Professor > Associate Professor 7 8%
Professor 5 5%
Other 9 10%
Unknown 11 12%
Readers by discipline
Readers by discipline Count As %
Chemistry 62 68%
Agricultural and Biological Sciences 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Biochemistry, Genetics and Molecular Biology 2 2%
Medicine and Dentistry 2 2%
Other 4 4%
Unknown 12 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2025.
All research outputs
#2,676,251
of 34,089,221 outputs
Outputs from Organic Letters
#422
of 22,434 outputs
Outputs of similar age
#9,864
of 149,345 outputs
Outputs of similar age from Organic Letters
#6
of 161 outputs
Altmetric has tracked 34,089,221 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,434 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 149,345 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.