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Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification

Overview of attention for article published in Acta Physiologica, April 2023
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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1 news outlet
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6 X users

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8 Dimensions

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19 Mendeley
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Title
Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification
Published in
Acta Physiologica, April 2023
DOI 10.1111/apha.13966
Pubmed ID
Authors

Dieter Kunz, Henrik Oster, Oliver Rawashdeh, Wolf‐Julian Neumann, Thomas Münte, Daniela Berg

Abstract

The global north is facing an unprecedented rise in the prevalence of neurodegenerative diseases. The increasing incidence of Parkinson's disease is being referred to as a pandemic. The reason for the enormous increase is only partly understood. Lifestyle factors are known to play a role, but they alone cannot account for the surge. One factor that - although being recognized as important - has not been explored in detail so far is the influence of circadian rhythms. Sleep and circadian rhythm disruption are known as key factors in neurodegeneration, and their occurrence during early disease stages suggests a causal role in the pathogenesis. Isolated rapid-eye movement (REM) sleep behaviour disorder (iRBD) has been identified as a prodromal state of α-synucleinopathies, such as Parkinson´s disease, Lewy body dementia, and multiple system atrophy offering a window for insights into the early development of these diseases. Even though REM sleep is the sleep state most pronounced driven and modulated by the circadian timing system, specific circadian abnormalities have not been described in iRBD. Novel experimental and clinical approaches exploiting the molecular circuitry underlying circadian timekeeping hold promise to disentangle some of the pathophysiologic mechanisms of α-synucleinopathies. In this review we summarize current knowledge on sleep and circadian rhythm disruptions in α-synucleinopathies with an emphasis on molecular aspects and therapeutic potentials. These insights might contribute to our understanding of the pathogenesis of neurodegenerative diseases and may allow therapeutic interventions addressing the disturbed circadian system at the early stage of disease.

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The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 11%
Student > Ph. D. Student 2 11%
Unspecified 1 5%
Other 1 5%
Professor 1 5%
Other 3 16%
Unknown 9 47%
Readers by discipline Count As %
Neuroscience 3 16%
Medicine and Dentistry 2 11%
Business, Management and Accounting 1 5%
Unspecified 1 5%
Environmental Science 1 5%
Other 1 5%
Unknown 10 53%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#2,679,843
of 24,975,845 outputs
Outputs from Acta Physiologica
#155
of 1,259 outputs
Outputs of similar age
#51,095
of 407,834 outputs
Outputs of similar age from Acta Physiologica
#6
of 22 outputs
Altmetric has tracked 24,975,845 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,259 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 407,834 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.