Mucosal melanoma is a rare, aggressive form of melanoma with extremely high recurrence rates despite definitive surgical resection with curative intent. Currently there is no consensus on adjuvant therapy. Data on checkpoint inhibitors (CPI) for adjuvant therapy is lacking.
We performed a single arm, multicenter clinical trial using "flip dose" ipilimumab (1mg/kg q3w x4 cycles), and nivolumab (3 mg/kg q3w x4 cycles), then Nivolumab 480 mg q4w x 11 cycles to complete a year of adjuvant therapy. Participants must have had R0/R1 resection <90 days prior to registration, no prior systemic therapy (adjuvant radiation allowed), ECOG 0/1, no uncontrolled autoimmune disease or other invasive cancer. Patients were recruited through the Midwest Melanoma Partnership/Hoosier Oncology Network.
From Sept 2017 to August 2021 35 patients enrolled. Of these, 29 (83%) had R0 resections, and 7 (20%) received adjuvant radiation. Median age was 67 years, 21 (60.0%) female. Relapse-free survival rates at 1 and 2 years were 50% (95% CI 31-66%) and 37% (95% CI 19-55%), respectively. Overall survival rates at 1 and 2 years were 87% (95% CI 68-95%) and 68% (95% CI 46-83%), respectively. Median RFS was 14.3 m (95% CI 5.7-25.8). Most common grade 3 toxicities were diarrhea (14%), hypertension (14%), and hyponatremia (11%), with no grade 4/5 toxicities.
Flip dose ipilimumab and nivolumab after resection of mucosal melanoma is associated with outcomes improved over that of surgical resection alone. Long term follow up, subgroup analyses and correlative studies are ongoing.
Pharmacology, Toxicology and Pharmaceutical Science
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5%
Environmental Science
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5%
Biochemistry, Genetics and Molecular Biology
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Unknown
11
58%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2023.
All research outputs
#7,633,606
of 30,056,308 outputs
Outputs from Clinical Cancer Research
#6,794
of 14,488 outputs
Outputs of similar age
#109,888
of 433,318 outputs
Outputs of similar age from Clinical Cancer Research
#60
of 110 outputs
Altmetric has tracked 30,056,308 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 14,488 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 433,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
