Title |
Oncolytic Reoviruses: Can These Emerging Zoonotic Reoviruses Be Tamed and Utilized?
|
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Published in |
DNA & Cell Biology, April 2023
|
DOI | 10.1089/dna.2022.0561 |
Pubmed ID | |
Authors |
Zhen Yun Siew, Alson Loh, Sharrada Segeran, Pooi Pooi Leong, Kenny Voon |
Abstract |
Orthoreovirus is a nonenveloped double-stranded RNA virus under the Reoviridae family. This group of viruses, especially mammalian orthoreovirus (MRV), are reported with great therapeutic values due to their oncolytic effects. In this review, the life cycle and oncolytic effect of MRV and a few emerging reoviruses were summarized. This article also highlights the challenges and strategies of utilizing MRV and the emerging reoviruses, avian orthoreovirus (ARV) and pteropine orthoreovirus (PRV), as oncolytic viruses (OVs). Besides, the emergence of potential ARV and PRV as OVs were discussed in comparison to MRV. Finally, the risk of reovirus as zoonosis or reverse zoonosis (zooanthroponosis) were debated, and concerns were raised in this article, which warrant continue surveillance of reovirus (MRV, ARV, and PRV) in animals, humans, and the environment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Netherlands | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 1 | 25% |
Researcher | 1 | 25% |
Student > Master | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Environmental Science | 1 | 25% |
Immunology and Microbiology | 1 | 25% |
Medicine and Dentistry | 1 | 25% |
Unknown | 1 | 25% |