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Human T follicular helper clones seed the germinal center–resident regulatory pool

Overview of attention for article published in Science Immunology, April 2023
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 1,047)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
87 news outlets
blogs
1 blog
twitter
127 X users
facebook
1 Facebook page

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
40 Mendeley
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Title
Human T follicular helper clones seed the germinal center–resident regulatory pool
Published in
Science Immunology, April 2023
DOI 10.1126/sciimmunol.ade8162
Pubmed ID
Authors

Carole Le Coz, Derek A Oldridge, Ramin S Herati, Nina De Luna, James Garifallou, Emylette Cruz Cabrera, Jonathan P Belman, Dana Pueschl, Luisa V Silva, Ainsley V C Knox, Whitney Reid, Samuel Yoon, Karen B Zur, Steven D Handler, Hakon Hakonarson, E John Wherry, Michael Gonzalez, Neil Romberg

Abstract

The mechanisms by which FOXP3+ T follicular regulatory (Tfr) cells simultaneously steer antibody formation toward microbe or vaccine recognition and away from self-reactivity remain incompletely understood. To explore underappreciated heterogeneity in human Tfr cell development, function, and localization, we used paired TCRVA/TCRVB sequencing to distinguish tonsillar Tfr cells that are clonally related to natural regulatory T cells (nTfr) from those likely induced from T follicular helper (Tfh) cells (iTfr). The proteins iTfr and nTfr cells differentially expressed were used to pinpoint their in situ locations via multiplex microscopy and establish their divergent functional roles. In silico analyses and in vitro tonsil organoid tracking models corroborated the existence of separate Treg-to-nTfr and Tfh-to-iTfr developmental trajectories. Our results identify human iTfr cells as a distinct CD38+, germinal center-resident, Tfh-descended subset that gains suppressive function while retaining the capacity to help B cells, whereas CD38- nTfr cells are elite suppressors primarily localized in follicular mantles. Interventions differentially targeting specific Tfr cell subsets may provide therapeutic opportunities to boost immunity or more precisely treat autoimmune diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 127 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 25%
Student > Ph. D. Student 9 23%
Student > Bachelor 6 15%
Student > Doctoral Student 2 5%
Other 2 5%
Other 3 8%
Unknown 8 20%
Readers by discipline Count As %
Immunology and Microbiology 15 38%
Biochemistry, Genetics and Molecular Biology 11 28%
Veterinary Science and Veterinary Medicine 1 3%
Agricultural and Biological Sciences 1 3%
Nursing and Health Professions 1 3%
Other 2 5%
Unknown 9 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 688. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2023.
All research outputs
#30,623
of 25,563,770 outputs
Outputs from Science Immunology
#34
of 1,047 outputs
Outputs of similar age
#818
of 422,068 outputs
Outputs of similar age from Science Immunology
#3
of 42 outputs
Altmetric has tracked 25,563,770 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,047 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 139.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,068 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.