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Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis

Overview of attention for article published in Expert Review of Gastroenterology and Hepatology, April 2023
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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17 X users

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Title
Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis
Published in
Expert Review of Gastroenterology and Hepatology, April 2023
DOI 10.1080/17474124.2023.2204229
Pubmed ID
Authors

Arup Choudhury, Anuraag Jena, Vaneet Jearth, Amit K Dutta, Govind Makharia, Usha Dutta, Mahesh Goenka, Rakesh Kochhar, Vishal Sharma

Abstract

Proton pump inhibitors (PPI) may impact the absorption of vitamin B12. We performed a systematic review to ascertain if PPI use increases risk of vitamin B12 deficiency. Electronic databases (Pubmed, Embase, Scopus) were searched on first of September 2022. We selected studies that compared the frequency of vitamin B12 deficiency in PPI users and non-users. Pooled Odds Ratio (OR) was calculated for the occurrence of vitamin B12 deficiency in PPI users compared to non-users. The risk of bias was assessed using the Newcastle Ottawa scale. Twenty-five studies were included. The pooled OR of vitamin B12 deficiency among PPI users (2852 participants) was higher than non-users (28070 participants) (OR 1.42, 95% CI: 1.16-1.73; I2 = 54%). Overall risk of PPI use among vitamin B12 deficient individuals was higher than those without deficiency (OR 1.49, 1.20-1.85; I2 = 68%). Most studies found no difference between serum vitamin B12 levels among PPI users compared to non-users. Although the pooled OR of vitamin B12 deficiency was slightly increased in PPI users, but there was significant heterogeneity, and the pooled OR was too low to imply an association clearly. Better-designed prospective studies in long-term users may clarify the issue. This study was not registered on PROSPERO.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 1 10%
Librarian 1 10%
Student > Ph. D. Student 1 10%
Professor > Associate Professor 1 10%
Student > Bachelor 1 10%
Other 0 0%
Unknown 5 50%
Readers by discipline Count As %
Medicine and Dentistry 2 20%
Social Sciences 1 10%
Nursing and Health Professions 1 10%
Unknown 6 60%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2023.
All research outputs
#3,283,602
of 25,425,223 outputs
Outputs from Expert Review of Gastroenterology and Hepatology
#69
of 773 outputs
Outputs of similar age
#62,436
of 413,528 outputs
Outputs of similar age from Expert Review of Gastroenterology and Hepatology
#1
of 17 outputs
Altmetric has tracked 25,425,223 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 773 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 413,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.