Wastewater treatment plants (WWTPs) are deemed a major conveyor and point source of per- and polyfluoroalkyl substances (PFAS) to the environment. This statistical meta-analysis of existing literature from the past 15 years focused on the significance of treatment type for PFAS removal efficiencies and the influence of PFAS sources (domestic vs. industrial) on their removal. Different sampling events, WWTPs across the world, different treatment technologies, configurations, and processes, as well as different PFAS classes and compounds were all considered. This study evaluated 13 PFAS analyzed predominately in 161 WWTPs across the world. The statistical test results showed that these 13 frequently detected and reported PFAS can be divided into four groups based on their behavior during wastewater treatment, namely 1) C6-10 perfluorocarboxylic acids (PFCAs), 2) C4,5,11,12 PFCAs, 3) C4,6,8 perfluoroalkane sulfonic acids (PFSAs), and 4) C10 PFSA. Within this study, biological treatments such as 1) membrane bioreactors, 2) combination of two or more biological treatments and 3) biofilm processes showed the highest PFAS removals, while the addition of a tertiary treatment actually had a non-beneficial effect on PFAS removal. Moreover, a strong statistical correlation was observed between industrial wastewater sources and the presence of high influent PFAS concentrations in the receiving WWTPs. This is an indication that industrial sources were the main contributors for the PFAS load in the analyzed WWTPs.