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A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health

Overview of attention for article published in Medicine and Science in Sports & Exercise, May 2023
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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9 news outlets
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116 X users
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2 Facebook pages
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5 YouTube creators

Citations

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55 Mendeley
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Title
A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health
Published in
Medicine and Science in Sports & Exercise, May 2023
DOI 10.1249/mss.0000000000003202
Pubmed ID
Authors

PHILIP D. CHILIBECK, DARREN G. CANDOW, JULIANNE J. GORDON, WHITNEY R. D. DUFF, RILEY MASON, KEELY SHAW, REGINA TAYLOR-GJEVRE, BINDU NAIR, GORDON A. ZELLO

Abstract

Our purpose was to examine the effects of 2 years of creatine monohydrate supplementation and exercise on bone health in postmenopausal women. 237 postmenopausal women (mean age 59y) were randomized to receive creatine (0.14 g·kg -1·day -1) or placebo during a resistance training (3d/wk) and walking (6d/wk) program for 2 years. Our primary outcome was femoral neck bone mineral density (BMD), with lumbar spine BMD, and proximal femur geometric properties as secondary outcomes. Compared to placebo, creatine supplementation had no effect on BMD of the femoral neck (creatine: 0.725 ± 0.110 to 0.712 ± 0.100; placebo: 0.721 ± 0.102 to 0.706 ± 0.097 g/cm2), total hip (creatine: 0.879 ± 0.118 to 0.872 ± 0.114; placebo: 0.881 ± 0.111 to 0.873 ± 0.109 g/cm2), or lumbar spine (creatine: 0.932 ± 0.133 to 0.925 ± 0.131; placebo: 0.923 ± 0.145 to 0.915 ± 0.143 g/cm2). Creatine significantly maintained section modulus (1.35 ± 0.29 to 1.34 ± 0.26 vs. placebo 1.34 ± 0.25 to 1.28 ± 0.23 cm3, p = 0.0011), predictive of bone bending strength, and buckling ratio (10.8 ± 2.6 to 11.1 ± 2.2 vs. placebo 11.0 ± 2.6 to 11.6 ± 2.7; p = 0.011), predictive of reduced cortical bending under compressive loads, at the narrow part of the femoral neck. Creatine reduced walking time over 80 meters (48.6 ± 5.6 to 47.1 ± 5.4 vs. placebo 48.3 ± 4.5 to 48.2 ± 4.9 s; p = 0.0008), but had no effect on muscular strength (i.e., 1RM) during the bench press (32.1 ± 12.7 to 42.6 ± 14.1 vs. placebo 30.6 ± 10.9 to 41.4 ± 14 kg) and hack squat (57.6 ± 21.6 to 84.4 ± 28.1 vs. placebo 56.6 ± 24.0 to 82.7 ± 25.0 kg). In sub-analysis of valid completers, creatine increased lean tissue mass compared to placebo (40.8 ± 5.7 to 43.1 ± 5.9 vs. placebo 40.4 ± 5.3 to 42.0 ± 5.2 kg; p = 0.046). Two years of creatine supplementation and exercise in postmenopausal women had no effect on bone mineral density, yet improved some bone geometric properties at the proximal femur.

X Demographics

X Demographics

The data shown below were collected from the profiles of 116 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 25 45%
Student > Ph. D. Student 3 5%
Researcher 3 5%
Student > Doctoral Student 2 4%
Student > Bachelor 2 4%
Other 3 5%
Unknown 17 31%
Readers by discipline Count As %
Unspecified 25 45%
Medicine and Dentistry 4 7%
Sports and Recreations 3 5%
Nursing and Health Professions 1 2%
Agricultural and Biological Sciences 1 2%
Other 4 7%
Unknown 17 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 141. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#295,129
of 25,522,520 outputs
Outputs from Medicine and Science in Sports & Exercise
#244
of 7,066 outputs
Outputs of similar age
#6,853
of 405,046 outputs
Outputs of similar age from Medicine and Science in Sports & Exercise
#5
of 64 outputs
Altmetric has tracked 25,522,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,066 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,046 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.