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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019
|
|---|---|
| Published in |
Journal of Infectious Diseases, May 2023
|
| DOI | 10.1093/infdis/jiad131 |
| Pubmed ID | |
| Authors |
Matthew S Durstenfeld, Michael J Peluso, Punita Kaveti, Christopher Hill, Danny Li, Erica Sander, Shreya Swaminathan, Victor M Arechiga, Scott Lu, Sarah A Goldberg, Rebecca Hoh, Ahmed Chenna, Brandon C Yee, John W Winslow, Christos J Petropoulos, J Daniel Kelly, David V Glidden, Timothy J Henrich, Jeffrey N Martin, Yoo Jin Lee, Mandar A Aras, Carlin S Long, Donald J Grandis, Steven G Deeks, Priscilla Y Hsue |
| Abstract |
Mechanisms underlying persistent cardiopulmonary symptoms following SARS-CoV-2 infection (post-acute sequelae of COVID-19 "PASC" or "Long COVID") remain unclear. This study sought to elucidate mechanisms of cardiopulmonary symptoms and reduced exercise capacity. We conducted cardiopulmonary exercise testing (CPET), cardiac magnetic resonance imaging (CMR) and ambulatory rhythm monitoring among adults > 1 year after confirmed SARS-CoV-2 infection in a post-COVID cohort, compared those with or without symptoms, and correlated findings with previously measured biomarkers. Sixty participants (median age 53, 42% female, 87% non-hospitalized) were studied at median 17.6 months following SARS-CoV-2 infection. On CPET, 18/37 (49%) with symptoms had reduced exercise capacity (<85% predicted) compared to 3/19 (16%) without symptoms (p = 0.02). Adjusted peak VO2 was 5.2 ml/kg/min lower (95%CI 2.1-8.3; p = 0.001) or 16.9% lower percent predicted (95%CI 4.3-29.6; p = 0.02) among those with symptoms. Chronotropic incompetence was common. Inflammatory markers and antibody levels early in PASC were negatively correlated with peak VO2 more than 1 year later. Late-gadolinium enhancement on CMR and arrhythmias were absent. Cardiopulmonary symptoms >1 year following COVID-19 were associated with reduced exercise capacity, which was associated with elevated inflammatory markers early in PASC. Chronotropic incompetence may explain exercise intolerance among some with cardiopulmonary Long COVID. |
X Demographics
The data shown below were collected from the profiles of 174 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 13% |
| United Kingdom | 14 | 8% |
| Japan | 9 | 5% |
| Germany | 5 | 3% |
| Canada | 3 | 2% |
| Sweden | 3 | 2% |
| France | 3 | 2% |
| Austria | 3 | 2% |
| Ireland | 2 | 1% |
| Other | 17 | 10% |
| Unknown | 92 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 149 | 86% |
| Practitioners (doctors, other healthcare professionals) | 11 | 6% |
| Scientists | 9 | 5% |
| Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 12% |
| Student > Master | 4 | 10% |
| Other | 3 | 7% |
| Unspecified | 2 | 5% |
| Student > Doctoral Student | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 22 | 54% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 20% |
| Unspecified | 2 | 5% |
| Nursing and Health Professions | 2 | 5% |
| Chemical Engineering | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 25 | 61% |
Attention Score in Context
This research output has an Altmetric Attention Score of 385. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2024.
All research outputs
#81,769
of 25,761,363 outputs
Outputs from Journal of Infectious Diseases
#93
of 14,912 outputs
Outputs of similar age
#2,087
of 404,828 outputs
Outputs of similar age from Journal of Infectious Diseases
#1
of 126 outputs
Altmetric has tracked 25,761,363 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,912 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,828 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.