Title |
Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa
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Published in |
Antimicrobial Agents and Chemotherapy, May 2023
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DOI | 10.1128/aac.00277-23 |
Pubmed ID | |
Authors |
Morgan K. Morelli, Amy Kloosterboer, Scott A. Fulton, Jennifer Furin, Nicholas Newman, Ahmed F. Omar, Laura J. Rojas, Steven H. Marshall, Mohamad Yasmin, Robert A. Bonomo |
Abstract |
Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of blaVIM-80, blaGES-9, and other resistance determinants. This distinctive organism was linked to an over-the-counter artificial tears product. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Guatemala | 1 | 14% |
Spain | 1 | 14% |
Mexico | 1 | 14% |
United States | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 21% |
Unspecified | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Lecturer | 1 | 7% |
Unknown | 8 | 57% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Unknown | 9 | 64% |