De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding

Overview of attention for article published in bioRxiv, May 2023

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RT @anshulkundaje: @muntakim_rafi It's pretty crazy what these tiny models learn. Also see The original Affinity Distillation paper https:…

@muntakim_rafi It's pretty crazy what these tiny models learn. Also see The original Affinity Distillation paper https://t.co/g9tqTdSmfB Zero shot recovery of thermodynamic impact of short tandem repeats flanking motifs https://t.co/MOprkhz6Ci (see Fi…

@KasperDHansen @ewanbirney If u are worried about "true" generalization, this should be convincing https://t.co/qynbDUSdQ6 Fig 1: NN trained on < 1000 PB-exo peaks in yeast genome generalizes zero-shot to ddGs from totally 10^6 library of very differ…

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