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@lifeanalytics and finally; https://t.co/cPHJ76B9qQ Loss of Sp1 (likely due to consistent activation via TLR4/adrenergic/other mechanisms) can contribute to aberrant mTOR activation which is rescued by rapamycin
The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex
Overview of attention for article published in Genes, Chromosomes, and Cancer, December 2009