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Sequence characterization and comparative expression profile of buffalo WNT10B gene in adult and fetal tissues

Overview of attention for article published in Animal Biotechnology, June 2023
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

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Title
Sequence characterization and comparative expression profile of buffalo WNT10B gene in adult and fetal tissues
Published in
Animal Biotechnology, June 2023
DOI 10.1080/10495398.2023.2225091
Pubmed ID
Authors

Deepu Verma, Manmohan Singh Chauhan, Shailendra Kumar Mishra, Kumbha Ramesh Babu, Karn Pratap Singh, Saroj Rani, Prem Kumar, Manoj Kumar Singh, Ankita Gurao, Ranjit Singh Kataria

Abstract

In this study, Wingless-type MMTV (mouse mammary tumor virus) integration site family member (WNT10B) gene was sequence characterized in the Indian water buffalo. Sequence analysis revealed an open reading frame of 1176 nucleotides in buffalo, encoding 391 amino acids long protein. Nineteen nucleotide variations were observed between cattle and buffalo resulting in six amino acid changes. Phylogenetic analysis showed the clustering of ruminant species together. Real-time expression analysis of WNT10B in tissues collected from different organs of fetal and adult buffalo, revealed, the gene being abundantly expressed in the rumen and liver of the fetus. The fetal ovary, heart, kidney, lung, testis and mammary gland showed moderate expression, while in adult tissues, expression was high in the ovary, testis, brain, kidney, small intestine and liver, whereas lower expression was observed in the adult rumen. Significant differences in WNT10B expression levels were found for the brain, small intestine, testes, kidney, heart, rumen, and ovary when adult and fetal tissues were compared. A moderate level of genetic variation was found between cattle and buffalo WNT10B and expression patterns in a variety of tissues in adult buffalo implies that in addition to possible roles in adipogenesis and hematopoiesis, the WNT10B gene might be playing a significant role in other regulatory pathways as well.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2023.
All research outputs
#14,241,285
of 23,942,155 outputs
Outputs from Animal Biotechnology
#99
of 375 outputs
Outputs of similar age
#76,003
of 181,837 outputs
Outputs of similar age from Animal Biotechnology
#1
of 5 outputs
Altmetric has tracked 23,942,155 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 375 research outputs from this source. They receive a mean Attention Score of 1.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 181,837 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them