Title |
ABO Blood Type and Metabolic Markers in COVID-19 Susceptibility and Severity: A Cross-Sectional Study
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Published in |
Metabolic Syndrome and Related Disorders, June 2023
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DOI | 10.1089/met.2023.0022 |
Pubmed ID | |
Authors |
Camila O. Arent, Alex Paulo Z. Padilha, Laura A. Borba, Taiane de Azevedo Cardoso, Monique C. André, Nicoly S. Martinello, Thayse Rosa, Helena M. Abelaira, Airam B. de Moura, Natalia M. Andrade, Amanda G. Bertollo, Gabriela G. de Oliveira, Margarete D. Bagatini, Zuleide Maria Ignácio, João Quevedo, Luciane B. Ceretta, Gislaine Z. Réus |
Abstract |
Background and Aims: To evaluate the effect of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus on the function and metabolic changes, as well as the relationship of the virus with blood groups. Methods and Results: This cross-sectional study included a matched sample of adult individuals with coronavirus disease 2019 (COVID-19) (n = 114) or without (controls; n = 236). Blood samples were collected and processed for triglycerides (TGs), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and blood typing analysis. The results showed that subjects with COVID-19 had higher TG and lower HDL-C levels compared with the control group. As for blood typing, the risk of COVID-19 was higher in subjects with blood group A than in those with blood group B and in those with other blood groups. In addition, an association of COVID-19 with blood type and Rh A- was observed. When related to the severity of COVID-19 symptoms, blood type A was more protective against moderate/severe symptoms compared with blood type O. In addition, individuals with blood type O were 2.90 times more likely to have symptoms moderate/severe symptoms of COVID-19 than those with other blood groups and individuals with type A blood were less likely to have severe/moderate symptoms of COVID-19 compared with individuals without type A blood. Conclusion: The results suggest that blood type may play a role in susceptibility to SARS-CoV-2 infection and add evidence that infection with the novel coronavirus may be associated with changes in lipid metabolism. |
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