You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells
|
|---|---|
| Published in |
Science Signaling, July 2023
|
| DOI | 10.1126/scisignal.abp9020 |
| Pubmed ID | |
| Authors |
Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, Etsuo A Susaki, Masanori Taira, Masanori Hatakeyama |
| Abstract |
Helicobacter pylori strains that deliver the oncoprotein CagA into gastric epithelial cells are the major etiologic agents of upper gastric diseases including gastric cancer. CagA promotes gastric carcinogenesis through interactions with multiple host proteins. Here, we show that CagA also disrupts Wnt-dependent planar cell polarity (Wnt/PCP), which orients cells within the plane of an epithelium and coordinates collective cell behaviors such as convergent extension to enable epithelial elongation during development. Ectopic expression of CagA in Xenopus laevis embryos impaired gastrulation, neural tube formation, and axis elongation, processes driven by convergent extension movements that depend on the Wnt/PCP pathway. Mice specifically expressing CagA in the stomach epithelium had longer pyloric glands and mislocalization of the tetraspanin proteins VANGL1 and VANGL2 (VANGL1/2), which are critical components of Wnt/PCP signaling. The increased pyloric gland length was due to hyperproliferation of cells at the gland base, where Lgr5+ stem and progenitor cells reside, and was associated with fewer differentiated enteroendocrine cells. In cultured human gastric epithelial cells, the N terminus of CagA interacted with the C-terminal cytoplasmic tails of VANGL1/2, which impaired Wnt/PCP signaling by inducing the mislocalization of VANGL1/2 from the plasma membrane to the cytoplasm. Thus, CagA may contribute to the development of gastric cancer by subverting a Wnt/PCP-dependent mechanism that restrains pyloric gland stem cell proliferation and promotes enteroendocrine differentiation. |
X Demographics
The data shown below were collected from the profiles of 240 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 35 | 15% |
| United States | 18 | 8% |
| Spain | 7 | 3% |
| United Kingdom | 6 | 3% |
| Mexico | 6 | 3% |
| Germany | 5 | 2% |
| India | 4 | 2% |
| Colombia | 3 | 1% |
| Canada | 3 | 1% |
| Other | 16 | 7% |
| Unknown | 137 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 209 | 87% |
| Scientists | 23 | 10% |
| Practitioners (doctors, other healthcare professionals) | 7 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 38% |
| Professor > Associate Professor | 2 | 15% |
| Student > Ph. D. Student | 1 | 8% |
| Student > Master | 1 | 8% |
| Student > Bachelor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 38% |
| Agricultural and Biological Sciences | 1 | 8% |
| Immunology and Microbiology | 1 | 8% |
| Psychology | 1 | 8% |
| Neuroscience | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 262. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2024.
All research outputs
#142,101
of 25,760,414 outputs
Outputs from Science Signaling
#16
of 3,551 outputs
Outputs of similar age
#2,935
of 366,221 outputs
Outputs of similar age from Science Signaling
#1
of 41 outputs
Altmetric has tracked 25,760,414 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,551 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 366,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.