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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Melatonin Inhibits Gastric Cancer Cell Proliferation by Suppressing Exosome miR-27b-3p Expression.
|
|---|---|
| Published in |
Anticancer Research: International Journal of Cancer Research and Treatment, September 2023
|
| DOI | 10.21873/anticanres.16637 |
| Pubmed ID | |
| Authors |
Yi-Qiang Zhang, Shuai-Shuai Shi, Yun-Fei Li, Yang Yang, Peng Bai, Chu-Han Qiao |
| Abstract |
In addition to its established role in regulating circadian rhythms and reducing inflammation, melatonin has been demonstrated to possess anti-cancer properties. In this study, we investigated the effects of exosomal miRNAs released by melatonin-treated GC cells on gastric cancer. To identify the potential exosomal miRNAs involved in the treatment of gastric cancer, we performed exosome small RNA sequencing (sRNA-seq) to screen significant changes in 34 exosomal miRNAs in AGS cells before and after melatonin treatment. CCK-8, wound healing, and transwell invasion assays were used to examine the effects of miRNAs on cancer characteristics. Furthermore, a dual-luciferase reporter gene assay was performed to identify the miRNA targets. Exosomal miR-27b-3p was down-regulated by approximately 1.37-fold following melatonin treatment. The CCK-8 assay revealed a significant increase in cell proliferation in the miR-27b-3p mimic group compared to that in the miR-27b-3p mimic NC group. In the wound healing assay, cells treated with miR-27b-3p mimics displayed significantly more rapid wound closure than that observed in the miR-27b-3p mimic NC group. The transwell invasion assay revealed a substantial increase in the number of invading cells in the miR-27b-3p mimic group compared to that in the miR-27b-3p mimic NC group. Additional analysis revealed that miR-27b-3p directly targets ADAMTS5 and that its up-regulation results in increased proliferation, invasion, and metastasis of GC cells. Melatonin suppressed the progression of gastric cancer by regulating the exosomal miR-27b-3p-ADAMTS5 pathway. Thus, melatonin represents a promising potential therapeutic agent for patients with gastric cancer. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Montenegro | 1 | 6% |
| Malaysia | 1 | 6% |
| Brazil | 1 | 6% |
| Mexico | 1 | 6% |
| Ukraine | 1 | 6% |
| United States | 1 | 6% |
| Canada | 1 | 6% |
| Poland | 1 | 6% |
| Unknown | 10 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 78% |
| Scientists | 3 | 17% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2023.
All research outputs
#4,275,880
of 25,806,763 outputs
Outputs from Anticancer Research: International Journal of Cancer Research and Treatment
#251
of 4,044 outputs
Outputs of similar age
#65,546
of 358,954 outputs
Outputs of similar age from Anticancer Research: International Journal of Cancer Research and Treatment
#3
of 42 outputs
Altmetric has tracked 25,806,763 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,044 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.