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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effect of childhood general traumas on suicide attempt depends on TPH2 and ADARB1 variants in psychiatric patients
|
|---|---|
| Published in |
Journal of Neural Transmission, January 2017
|
| DOI | 10.1007/s00702-017-1677-z |
| Pubmed ID | |
| Authors |
Jelena Karanović, Maja Ivković, Vladimir M. Jovanović, Saša Šviković, Maja Pantović-Stefanović, Miloš Brkušanin, Aleksandar Damjanović, Goran Brajušković, Dušanka Savić-Pavićević |
| Abstract |
Suicidal behavior has been associated with a deficient serotonin neurotransmission which is likely a consequence of individual genetic architecture, exposure to environmental factors and interactions of those factors. We examined whether the interaction of child abuse, TPH2 (tryptophan hydroxylase 2) variant rs4290270, affecting alternative splicing and editing of TPH2 pre-mRNAs, and ADARB1 (adenosine deaminase acting on RNA B1) variants rs4819035 and rs9983925 may influence the risk for suicide attempt in psychiatric patients. TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia. Genotyping data for ADARB1 variants were taken over from our previous study. Child abuse before the age of 18 years was assessed using the Early Trauma Inventory-Self Report. Generalized linear models and backward selection were applied to identify the main and interacting effects of environmental and genetic factors, including psychiatric diagnoses, patients' gender and age as covariates. Childhood general traumas were independently associated with suicide attempt. Two-way interaction between TPH2 rs4290270 and general traumas revealed that TT homozygotes with a history of general traumas had an increased risk for suicide attempt. Three-way interaction of general traumas, TPH2 rs4290270 and ADARB1 rs4819035 indicated that the highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035. Our findings suggest that the risk for suicide attempt in psychiatric patients exposed to an adverse childhood environment may depend on TPH2 and ADARB1 variants. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 1% |
| Unknown | 79 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 19% |
| Student > Bachelor | 9 | 11% |
| Researcher | 7 | 9% |
| Student > Ph. D. Student | 6 | 8% |
| Student > Postgraduate | 4 | 5% |
| Other | 11 | 14% |
| Unknown | 28 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 14% |
| Medicine and Dentistry | 11 | 14% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Social Sciences | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 9 | 11% |
| Unknown | 37 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
All research outputs
#17,863,974
of 22,940,083 outputs
Outputs from Journal of Neural Transmission
#1,363
of 1,774 outputs
Outputs of similar age
#294,633
of 421,590 outputs
Outputs of similar age from Journal of Neural Transmission
#22
of 32 outputs
Altmetric has tracked 22,940,083 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,774 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,590 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.