Title |
A low-fat diet improves fatigue in multiple sclerosis: Results from a randomized controlled trial
|
---|---|
Published in |
Multiple Sclerosis Journal, November 2023
|
DOI | 10.1177/13524585231208330 |
Pubmed ID | |
Authors |
Emma Chase, Vicky Chen, Kayla Martin, Michael Lane, Lindsey Wooliscroft, Claire Adams, Jessica Rice, Elizabeth Silbermann, Christopher Hollen, Allison Fryman, Jonathan Q Purnell, Carly Vong, Anna Orban, Angela Horgan, Akram Khan, Priya Srikanth, Vijayshree Yadav |
Abstract |
Fatigue can be a disabling multiple sclerosis (MS) symptom with no effective treatment options. Determine whether a low-fat diet improves fatigue in people with MS (PwMS). We conducted a 16-week randomized controlled trial (RCT) and allocated PwMS to a low-fat diet (active, total daily fat calories not exceeding 20%) or wait-list (control) group. Subjects underwent 2 weeks of baseline diet data collection (24-hour diet recalls (24HDRs)), followed by randomization. The active group received 2 weeks of nutrition counseling and underwent a 12-week low-fat diet intervention. One set of three 24HDRs at baseline and week 16 were collected. We administered a food frequency questionnaire (FFQ) and Modified Fatigue Impact Scale (MFIS) every 4 weeks. The control group continued their pre-study diet and received diet training during the study completion. We recruited 39 PwMS (20-active; 19-control). The active group decreased their daily caloric intake by 11% (95% confidence interval (CI): -18.5%, -3.0%) and the mean MFIS by 4.0 (95% CI: -12.0, 4.0) compared to the control (intent-to-treat). Sensitivity analysis strengthened the association with a mean MFIS difference of -13.9 (95% CI: -20.7, -7.2). We demonstrated a significant reduction in fatigue with a low-fat dietary intervention in PwMS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 20% |
Belgium | 1 | 10% |
United States | 1 | 10% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 50% |
Practitioners (doctors, other healthcare professionals) | 3 | 30% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 4 | 20% |
Student > Ph. D. Student | 4 | 20% |
Researcher | 3 | 15% |
Student > Master | 2 | 10% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 4 | 20% |
Nursing and Health Professions | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Neuroscience | 2 | 10% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |