Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level. Studies aimed at clarifying their physiological importance have suggested roles for ASICs in pain, neurological and psychiatric disease. This Review highlights recent findings linking these channels to physiology and disease. In addition, it discusses some of the implications for therapy and points out questions that remain unanswered.
Pharmacology, Toxicology and Pharmaceutical Science
24
5%
Other
67
13%
Unknown
122
24%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2026.
All research outputs
#1,775,411
of 31,990,159 outputs
Outputs from Nature Reviews Neuroscience
#764
of 2,995 outputs
Outputs of similar age
#12,823
of 231,920 outputs
Outputs of similar age from Nature Reviews Neuroscience
#8
of 60 outputs
Altmetric has tracked 31,990,159 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,995 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.8. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.
