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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gut microbiota defined epigenomes of Alzheimer's and Parkinson's diseases reveal novel targets for therapy
|
|---|---|
| Published in |
Epigenomics, December 2023
|
| DOI | 10.2217/epi-2023-0342 |
| Pubmed ID | |
| Authors |
Shabnam Nohesara, Hamid Mostafavi Abdolmaleky, Sam Thiagalingam, Jin-Rong Zhou |
| Abstract |
The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The gut microbiota's dynamic composition and its metabolites influence intestinal and blood-brain barrier integrity, contributing to AD and PD development. This review explores protein misfolding, aggregation and epigenetic links in AD and PD pathogenesis. It also highlights the role of a leaky gut and the microbiota-gut-brain axis in promoting these diseases through inflammation-induced epigenetic alterations. In addition, we investigate the potential of diet, probiotics and microbiota transplantation for preventing and treating AD and PD via epigenetic modifications, along with a discussion related to current challenges and future considerations. These approaches offer promise for translating research findings into practical clinical applications. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 16 | 80% |
| Student > Master | 1 | 5% |
| Student > Postgraduate | 1 | 5% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 16 | 80% |
| Medicine and Dentistry | 1 | 5% |
| Neuroscience | 1 | 5% |
| Unknown | 2 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2023.
All research outputs
#3,277,850
of 25,393,528 outputs
Outputs from Epigenomics
#94
of 1,152 outputs
Outputs of similar age
#46,553
of 343,479 outputs
Outputs of similar age from Epigenomics
#3
of 33 outputs
Altmetric has tracked 25,393,528 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,152 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.