Note: The story of Pleiotropy "The investigation of the ability of two models to provide robustness to #pleiotropy under the IVW approach, and propose statistics to quantify the relative goodness‐of‐fit of the #IVW approach over #MR_Egger regression." h…
@lukejostins @zkutalik @stevesphd read section 3.1 and 3.2 in https://t.co/4YZQl3tylj which tells you the difference between additive and multiplicative random effects models for pleiotropy. Usually it doesn't matter if you miss-specify but when you hav…
@stevesphd @lukejostins MR-Egger generally yields imprecise estimates compared to other MR approaches, the data really needs a high I^{2}_{GX} statistic to use it reliably at all. It is also v. sensitive to InSIDE violation. further explanation here +…
@GENES_PK pathways to smoking have the same effect on SZ. This is not biologically very plausible. We should (and will in revised version) have reported heterogeneity statistics within the Rucker framework, apologies we didn't https://t.co/I4K6gLkDbA