Triggering receptor expressed on myeloid cells (TREM)-1 has recently been recognized as one of the potent amplifiers of acute and chronic inflammation. However, the exact role of TREM-1 in regard to insulin insensitivity is unknown.
mRNA transcripts and protein expression of TREM-1, TREM-2, and TREM-1/TREM-2 ratio were examined in the tissue biopsies (liver, omentum, and subcutaneous fat) and blood samples (neutrophils and monocytes) of subjects with obesity and diabetes (SO(+) D(+) ; n = 15), subjects with obesity but not diabetes (SO(+) D(-) ; n = 7), and subjects without obesity (BMI < 30) and diabetes (SO(-) D(-) ; n = 5).
The immunofluorescence and RT-PCR revealed significant increase in TREM-1, decrease in TREM-2, and increase in the TREM1/TREM2 ratio in SO(+) D(+) group compared with other groups. Overall, increased liver TREM-1 expression and soluble-TREM-1 were found in SO(+) D(+) group compared with SO(+) D(-) group (100% vs. 57.14%, r = 0.582; P = 0.023). TREM-1 was significantly increased in all subjects with obesity and those with HOMA-IR index of >2.
TREM-1 was found to be significantly higher in tissues biopsies and blood of subjects with obesity. Greater expression and activity of TREM-1 suggest a possible role in the underlying pathophysiology of obesity and associated comorbidities.
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2017.
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#3,159,498
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#63,109
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Outputs of similar age from Obesity
#31
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Altmetric has tracked 24,471,305 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,217 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
