Unexpected Effect of Proton Pump Inhibitors

Overview of attention for article published in Circulation, July 2013

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https://t.co/FjhINQNT0S 急性冠症候群の複数研究でPPIで主要心血管event⬆️懸念 🩸非対称dimethylarginine(ADMA)はNO合成酵素(NOS)阻害剤 🩸ADMA⬆️🤝心血管疾患⬆️:内皮型NOS血管保護⬇️の為 PPIは🐭,👥ex vivo組織でADMA⬆️NO,内皮依存性血管拡張⬇️させる PPIはADMA分解酵素DD…

https://t.co/FjhINQNT0S ADMAはdimethylarginine dimethylaminohydrolase(DDAH) で80%代謝 ADMAは一酸化窒素(NO)合成酵素(NOS)の競合阻害剤内皮NOS(eNOS)は高度制御,局所少量NO産生,血管恒常性維持に影響 PPIの阻害等でADMA⬆️⇨eNOS活性阻害,NO産生⬇️ eNOS血管保護作用が喪…

RT @PharmaQahtan: مصدر علمي: Ghebremariam YT et al. Unexpected Effect of Proton Pump Inhibitors. Circulation. 2013;128(8):845–853. https:/…

مصدر علمي: Ghebremariam YT et al. Unexpected Effect of Proton Pump Inhibitors. Circulation. 2013;128(8):845–853. https://t.co/y00YQwc7Pd

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