| Title |
Self-Assembled DNA Tubes Forming Helices of Controlled Diameter and Chirality
|
|---|---|
| Published in |
ACS Nano, January 2017
|
| DOI | 10.1021/acsnano.6b05602 |
| Pubmed ID | |
| Authors |
Alexander Mario Maier, Wooli Bae, Daniel Schiffels, Johannes Friedrich Emmerig, Maximilian Schiff, Tim Liedl |
| Abstract |
Multihelical DNA bundles could enhance the functionality of nanomaterials and serve as model architectures to mimic protein filaments on the molecular and cellular level. We report the self-assembly of micrometer-sized helical DNA nanotubes with widely controllable helical diameters ranging from tens of nanometers to a few micrometers. Nanoscale helical shapes of DNA tile tubes (4, 6, 8, 10 and 12-helix tile tubes) are achieved by introducing discrete amounts of bending and twist through base pair insertions and/or deletions. Microscale helical diameters, which require smaller amounts of twist and bending, are achieved by controlling the intrinsic "supertwist" present in tile tubes with uneven number of helices (11, 13 and 15-helix tile tubes). Supertwist fine-tuning also allows us to produce helical nanotubes of defined chirality. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 29% |
| Researcher | 9 | 17% |
| Student > Bachelor | 5 | 10% |
| Student > Master | 4 | 8% |
| Lecturer > Senior Lecturer | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 12 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 15 | 29% |
| Physics and Astronomy | 6 | 12% |
| Engineering | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 14 | 27% |