Title |
Kidney damage associated with COVID-19: from the acute to the chronic phase
|
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Published in |
Renal Failure, April 2024
|
DOI | 10.1080/0886022x.2024.2316885 |
Pubmed ID | |
Authors |
Yannick Nlandu, Elliot Koranteng Tannor, Titilope Bafemika, Jean-Robert Makulo |
Abstract |
Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. The most common form of glomerular injury is collapsing glomerulopathy (CG), which is strongly associated with apolipoprotein L1(APOL-1) risk variants. These acute lesions, which are secondary to the direct or indirect effects of SARS-CoV-2, can progress to chronicity and are specific to long COVID-19 in the absence of any other cause. Residual inflammation associated with SARS-CoV-2 infection, in addition to acute kidney injury (AKI) as a transitional state with or without severe histological lesions, may be responsible for greater kidney function decline in mild-to-moderate COVID-19. This review discusses the evidence for renal histological markers of chronicity in COVID-19 patients and triggers of low-grade inflammation that may explain the decline in kidney function in the post-COVID-19 period. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 22 | 10% |
Spain | 18 | 8% |
Canada | 8 | 3% |
Australia | 8 | 3% |
France | 8 | 3% |
United Kingdom | 7 | 3% |
Japan | 5 | 2% |
Germany | 5 | 2% |
Brazil | 4 | 2% |
Other | 21 | 9% |
Unknown | 125 | 54% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 202 | 87% |
Scientists | 14 | 6% |
Practitioners (doctors, other healthcare professionals) | 12 | 5% |
Science communicators (journalists, bloggers, editors) | 3 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 29% |
Unspecified | 1 | 14% |
Researcher | 1 | 14% |
Other | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 43% |
Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Unspecified | 1 | 14% |
Unknown | 2 | 29% |