Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2024

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RT @interactivefly: Ma, D., Ojha, P., Yu, A. D., ..., Joiner, W. J., Abruzzi, K. C., Rosbash, M. (2024). Timeless noncoding DNA contains ce…

Ma, D., Ojha, P., Yu, A. D., ..., Joiner, W. J., Abruzzi, K. C., Rosbash, M. (2024). Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation. Proc Natl Acad Sci U S A, 121(15):e2321338121 htt…

ハエの2つの転写因子ClockとCycleはE-boxと言う配列に結合し,feedback loopで概日リズムを制御する. この制御を受けるtimelessは,転写抑制因子をコードし,夜間に蓄積しClockの転写を抑制する. この論文では,timeless2つのE-boxが,細胞種で使い分けられている可能性を指摘した…

Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation https://t.co/KdZWaGTZ2T

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