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Attention Score in Context
| Title |
Immunogenic Material Vaccine for Cancer Immunotherapy by Structure‐Dependent Immune Cell Trafficking and Modulation
|
|---|---|
| Published in |
Advanced Materials, April 2024
|
| DOI | 10.1002/adma.202402580 |
| Pubmed ID | |
| Authors |
Wei Yang, Jianwei Cao, Sichen Di, Wenjin Chen, Hui Cheng, Hongze Ren, Yujie Xie, Liang Chen, Meihua Yu, Yu Chen, Xingang Cui |
| Abstract |
Inherently immunogenic materials offer enormous prospects in enhancing vaccine efficacy. However, the understanding and improving material adjuvanticity remain elusive. Herein we report how the structural presentation of immunopotentiators in a material governs the dynamic dialogue between innate and adaptive immunity for enhanced cancer vaccination. We precisely manipulate the immunopotentiator manganese into six differing structures that resemble the architectures of two types of pathogens (spherical viruses or rod-like bacteria). The results reveal that innate immune cells accurately sense and respond to the architectures, of which two outperformed material candidates (151 nm hollow spheres and hollow micro-rods with an aspect ratio of 4.5) show higher competence in creating local pro-inflammatory environment with promoted innate immune cell influx and stimulatory effects on multiple subsets of dendritic cells (DCs). In combination with viral peptides, model proteins or cell lysate antigens, mature CD103+ (CD8+) DCs and CD11b+ DCs induced by the outperformed micro-rod material remarkably primes antigen-specific CD8+ and CD4+ cytolytic T cells, respectively. The micro-rod stimulates DCs with enriched gene signatures associated with plasmacytoid DC, potentially contributing to enhanced type-I interferon (IFN) mediated cellular immunity. In prophylactic and therapeutic regimens, the micro-rod adjuvanted vaccines display optimal aptitude in tumor suppression universally in four aggressive malignant murine tumor models, by promoting the infiltration of heterogeneous cytolytic effector cells while decreasing suppressive immunoregulatory populations in tumors. This study demonstrates that a rationally selected architecture of immunogenic materials potentially advances the clinical reality of cancer vaccination . This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Members of the public | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2024.
All research outputs
#3,621,505
of 25,838,141 outputs
Outputs from Advanced Materials
#3,417
of 18,444 outputs
Outputs of similar age
#24,234
of 178,973 outputs
Outputs of similar age from Advanced Materials
#32
of 563 outputs
Altmetric has tracked 25,838,141 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,444 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,973 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 563 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.