TIM-3+ CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies

@DelgoffeLab @HBorgesdaSilva Here’s the full paper: https://t.co/L2W4hxcuuI But basically, they make IFNg, perforin and granzyme B with potent ex vivo killing (same level as CX3CR1+ effector cells).

(すごい遅れちゃってるけど) 多発性骨髄腫への移植やCAR-Tなどの系、過去文献データなどを活用し、Tim-3発現など疲弊の表現型を示しながらINFγも産生するT細胞集団(Tphex)についてcharacterize。Batfが大事そうなこと、expansionはしないのでTpexを狙うのが重要そうなことも…

RT @IOTNmoonshot: Dr. Simone Minnie @simone_minnie from @fredhutch shares their findings that CD8 T cells, despite an exhausted phenotype,…

RT @IOTNmoonshot: Dr. Simone Minnie @simone_minnie from @fredhutch shares their findings that CD8 T cells, despite an exhausted phenotype,…