CD138 as a Specific CSF Biomarker of Multiple Sclerosis

Overview of attention for article published in Neurology: Neuroimmunology and Neuroinflammation, April 2024

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In the top 25% of all research outputs scored by Altmetric
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RT @NeuroSjogrens: Is there a marker that may distinguish Sjogrens from MS? This study only included 1 NeuroSjogrens pt as a control, but…

https://t.co/58Xi0hMhrm "These findings identify CD138 as a specific CSF biomarker for MS and suggest the selective activation of the chitinase 3–like protein 1/CD138 pathway within the oligodendrocyte lineage in MS."

https://t.co/58Xi0hMhrm "CD138 immunostaining was also observed in the brains of patients with MS and cultured oligodendrocyte precursor cells but was absent in astrocytes."

https://t.co/58Xi0hMhrm "CD138 exhibited good diagnostic accuracy in distinguishing MS from inflammatory neurologic disorders (area under the curve [AUC] = 0.85, CI 0.75–0.95)."

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