Effective #CRISPR/Cas9 gene editing in skeletal muscle relies on Cas9 reaching all myonuclei. "Myospreader," a peptide combination, enhances Cas9 propagation, improving gene editing in muscular dystrophy models. Daily biotech insights 👉🏼 @gathersight. h…
"Myospreader improves gene editing in skeletal muscle by myonuclear propagation" Poukalov KK [..] Wang ET. PNAS. 2024-04-30/05-07 https://t.co/41sU9wWnPR Append a modular, compact peptide tag “myospreader” to #CRISPR-dCas9 to promote myonuclear propagati…
Myospreader improves gene editing in skeletal muscle by myonuclear propagation | PNAS https://t.co/7JVw6yI2vg of note: elegant engineering based on sequence analysis and cell biology of immediate relevance to muscle anatomy (long - really long - syncyti…
RT @KPoukalov: Happy to announce my PhD work is published!🎉 @PNASNews : Myospreader improves gene editing in skeletal muscle by myonuclear…