The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies

Overview of attention for article published in Nature Reviews Rheumatology, July 2024

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#2024GCAN Basic Science year in review for gout ⭐️ @LeaskMegan - review on gout pathogenesis in @NatRevRheumatol https://t.co/CZ2tfiYQjO #ACR24

https://t.co/xWkysCGW8a "- The translation of genetic signals into mechanistic knowledge requires experimental studies, which are gradually being conducted in loci such as ABCG2, PDZK1, MAF and HNF4A."

https://t.co/xWkysCGW8a "- Genome-wide association studies of gout are yet to be conducted in under-represented populations; however, the identification of population-specific genetic variants is providing new insights into the pathogenesis of gout."

https://t.co/xWkysCGW8a "- Genome-wide association studies of gout highlight the importance of epigenomic pathways, suggesting that epigenetic reprogramming of innate immune cells by soluble urate increases their responsiveness to monosodium urate crys…

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