The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis

Overview of attention for article published in Journal of Clinical Investigation, June 2024

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Study highlights critical role of E/I balance in #MultipleSclerosis #neurodegeneration. Chronic hyperexcitability drives neuronal loss via NR4A2-mediated VGF secretion. Targeting this pathway could offer new therapeutic avenues. https://t.co/0xn1O1RLxN …

"The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis" in the Journal of Clinical Investigation. Again, high rates of glycolysis are bad for neurons https://t.co/K3slXjGI6f

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